Al(OTf)₃ Lewis Acid Catalyst Aluminum Trifluoromethanesulfonate CAS 74974-61-1

1. Key Application Areas

1. Organic Synthesis Catalyst

   • Lewis Acid Catalysis: Used for esterification, Friedel-Crafts alkylation/acylation, and Diels-Alder reactions.

   • Sugar Conversion: Catalyzes the transformation of glucose into 5-hydroxymethylfurfural (5-HMF).

   • Cooperative Catalysis: Works with palladium catalysts (e.g., Pd(OAc)₂/BINAP) in methoxycarbonylation of phenylacetylene.

2. Polymer Materials

   • Serves as an electrolyte additive to enhance electrochemical properties (e.g., ionic conductivity) in polymers.

3. Pharmaceutical Intermediates

   • Classified by some suppliers as building blocks for drug molecule synthesis.

2. Safety Information

• Hazards:

  • Corrosive: Causes severe skin/eye burns (Risk Code: C).

  • Environmental Toxicity: Harmful to aquatic life (WGK Germany: 3).

• Protective Measures:

  • Wear gloves, goggles, and lab coats during handling.

  • Store separately from acids, bases, and oxidizers.

• Transport Code: UN 3261 (Corrosive solid, Class 8).

3. Important Notes

• Solubility Optimization: For aqueous applications, consider surfactant blending or nanoparticle preparation.

• Light Sensitivity: Requires light-protected storage/operation to prevent degradation.

• Toxicity Consideration: High molecular weight (474.19 g/mol) suggests low dermal absorption risk, though full toxicological data remains limited.